Mapping Highly Congested Proton NMR Spin Systems of Natural Products Using Two-Dimensional Proton Double Quantum Coherence |
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| Authors: | Gary E Martin Steven C Welch |
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| Institution: | 1. Department of Medicinal Chemistry , College of Pharmacy University of Houston , Houston, Texas, 77004;2. Department of Chemistry , University of Houston , Houston, Texas, 77004 |
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| Abstract: | Highly congested terpenoid proton NMR spectra are generally intractable to detailed analysis and assignment. Analyses of the proton-proton connectivity networks in such spectra are, however, possible using the proton double quantum coherence two-dimensional NMR experiment. Natural cycloseychellene, which contains resonances for twenty four protons within a 1.2 ppm wide region is used as an example to demonstrate this technique. |
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| Keywords: | two-dimensional nmr proton double quantum coherence natrual products cycloseychellene |
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