IR Evidences for N-9 and N-7 Regioisomers of the Acyclic Purine Nucleoside Analogues |
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| Authors: | Silvana Rai´ Mario Pongraĉić Mladen Mintas |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemical Engineering and Technology , University of Zagreb , Zagreb, Croatia;2. Pliva Research Institute , Prilaz Baruna Filipovi?a 25, Zagreb, 10000, Croatia |
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| Abstract: | The IR spectra have been recorded in the solid state for the parent molecule, 6-(N-pyrrolyl)purine (1) and its N-9-and N-7-substituted derivatives: 9-and 7-(2-hydroxyprop-1-yl)-6-(N-pyrrol-1-yl)purine (2 and 3), 9-and 7-(2-acetoxyprop-1-yl)-6-(N-pyrrol-1-yl)purine (4 and 5), 9-and 7-(2,3-dihydroxyprop-1-yl)-6-(N-pyrrol-1-yl)purine (6 and 7) as well as 9-and 7-(2,3-diacetoxyprop-1-yl)-6-(N-pyrrol-1-yl)purine (8 and 9). Analysis of the characteristic bands has proved to be useful in differentiating between N-9 and N-7 regioisomers. |
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| Keywords: | Acyclic Nucleoside Analogues Purine N-9 and N-7 Regioisomers IR Spectroscopy |
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