Quantitavive Proton Magnetic Resonance Analysis of Ranitidine in Solid Dosage Forms |
| |
| Authors: | Tuncel Özden Ahmet Üngörmüş Ali Tosun Seyhan Ersan |
| |
| Institution: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Gazi University , Ankara, Turkey |
| |
| Abstract: | A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d6 served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 δ ppm and int. st. at 5.19 δ ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII. |
| |
| Keywords: | PMR Analysis Ranitidine |
|
|
