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Quantitative Analysis of Acetazolamide in Solid Dosage Forms with 1H-Nmr Spectroscopy |
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| Authors: | Hamide şenyuva Tuncel özden İnci Akşahin |
| Institution: | 1. Instrumental Analysis Centre, Scientific and Technical Research Council of Turkey , 06330, Ankara, Turkey;2. Faculty of Pharmacy , Gazi University , Be?evler, Ankara, 06330, Turkey |
| Abstract: | A rapid and specific proton magnetic resonance spectroscopic method was developed for determining acetazolamide in tablets. Maleic acid was used as the internal standard and DMSO-d6 served as the NMR solvent. the concentration of drug per unit dose was calculated from the integration values for the resonance signals of acetazolamide at 2.14 ppm and maleic acid at 6.20 ppm. the method using commercial products gave comparable results of those obtained by the method of USP XXIII. |
| Keywords: | Acetazolamide Quantitative Analysis 1H-NMR |