Determination of Busulfan in Tablets by NMR Spectroscopy |
| |
| Authors: | John Turczan Cesar Lau-cam |
| |
| Affiliation: | 1. Food and Drug Administration New York Regional Laboratory , Brooklyn, New York, 11232;2. St. John's University, College of Pharmacy &3. Allied Health Professions , Jamaica, New York, 11439 |
| |
| Abstract: | A simple NMR spectroscopic method is described for the assay of busulfan in tablets. Methenamine is used as the internal standard and chloroform-d as the solvent. The mean recovery value for the drug from standard mixtures was 99.3 ± 0.182% w/w (n = 5) by the NMR method and 99.2% (n = 2) by the official method. The mean content of busulfan in commercial tablet samples was 99.4 ± 0.16 (range 99.1 – 99.6)% w/w (CV = 0.16%, n = 10) by the NMR method and 99.5 ± 0.17 (range 99.2 – 99.8)% w/w (CV = 0.17%, n = 10) by the official method. |
| |
| Keywords: | Busulfan NMR Analysis Busulfan Tablets NMR Analysis. |
|
|
