Spectral Data of Chemical Modification Products of Costunolide |
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| Authors: | Tiansheng Lu Nikolaus H Fischer |
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| Institution: | Department of Chemistry , Louisiana State University , Baton Rouge , Louisiana , 70803 , U. S. A. |
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| Abstract: | Epoxidation of costunolide (1) yielded parthenolide (3), 1, 10-epoxycostunolide (4), and the cyclization products of 4, santamarin (5), reynosin (6), magnolialide (7) and a 1, 4-epoxyeudesmanolide (8). Reduction of santamarin (5) with sodium borohydride afforded 11, 13-dihydrosantamarin (9) and an eudesmen-triol (10). Reduction of reynosin (6) provided 11, 13-dihydroreynosin (11) and the two eudesman-triols 12 and 13. The structures of the new compounds were elucidated by ID and 2D 1H and 13C NMR spectral methods. |
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| Keywords: | Sesquiterpene lactones germacranolides costunolide epoxidation-cyclization parthenolide 1 10-epoxycostunolide eudesmanolides reductions 1H and 13C NMR |
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