| 不同溶剂制备的聚乳酸多孔微球的形成机理 |
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| 引用本文： | 石旭东,孙磊,甘志华.不同溶剂制备的聚乳酸多孔微球的形成机理[J].高分子学报,2011(8):866-873. |
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| 作者姓名： | 石旭东 孙磊 甘志华 |
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| 作者单位： | 1. 中国科学院化学研究所 工程塑料院重点实验室 北京100190
2. 北京积水潭医院北京市创伤骨科研究所 北京100035 |
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| 摘 要： | 利用改进的双乳液溶剂挥发法制备了多孔聚乳酸( PLA)微球.通过采用具有不同沸点和水溶性的有机溶剂制备得到不同多孔结构的PLA微球.结果发现以二氯甲烷、氯仿和甲苯为溶剂制备的微球具有相似的均匀多孔结构,而以乙酸乙酯制备的微球却具有中空结构和多孔的壳层.通过进一步的实验研究了溶剂种类对于微球多孔结构的影响.结果表明溶剂的...
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| 关 键 词： | 聚乳酸 多孔微球 溶剂移出速率 |
FORMATION MECHANISM OF SOLVENT-INDUCED POROUS PLA MICROSPHERES |
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| SHI Xudong,SUN Lei,GAN Zhihua.FORMATION MECHANISM OF SOLVENT-INDUCED POROUS PLA MICROSPHERES[J].Acta Polymerica Sinica,2011(8):866-873. |
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| Authors: | SHI Xudong SUN Lei GAN Zhihua |
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| Abstract: | Porous polylactide (PLA) microspheres were prepared by means of the modified double emulsion solvent evaporation. The organic solvents with different boiling points and aqueous solubility were used to prepare PLA microspheres with different porous structures.Microspheres prepared with methylene chloride,chloroform and toluene as solvents had the similar homogeneous porous structure,while those microspheres with ethyl acetate as solvent showed a hollow structure with a porous thin shell.The effects of solvent types on porous structure of microspheres were discussed.It was concluded that the removal rate of solvent plays the decisive role in determining the porous structure of microspheres.Accordingly,a formation mechanism of porous microspheres fabricated with different solvents was proposed. |
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| Keywords: | Polylactide Porous microspheres Solvent removal rate |
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