“Post‐It” Type Connected DNA Created with a Reversible Covalent Cross‐Link |
| |
| Authors: | Dr María Tomás‐Gamasa M?Sc Sascha Serdjukow M?Sc Meng Su Dr Markus Müller Prof?Dr Thomas Carell |
| |
| Institution: | Department of Chemistry and Pharmacy, Ludwig‐Maximilians‐Universit?t München, Butenandtstrasse 5–13, 81377 München (Germany) http://www.carellgroup.de |
| |
| Abstract: | We report the development of a new heterobase that is held together through reversible bonding. The so‐formed cross‐link adds strong stabilization to the DNA duplex. Despite this, the cross‐link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross‐link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications. |
| |
| Keywords: | DNA DNA cross‐linking DNA nanostructures imines reversible bonding |
|
