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Crystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO2 |
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| Authors: | Sarah L Ackermann Dr David J Wolstenholme Chris Frazee Dr Ghislain Deslongchamps Sandra H M Riley Dr Andreas Decken Dr G Sean McGrady |
| Institution: | Department of Chemistry, University of New Brunswick, P.O. Box 4400, Fredericton, N.B., E3B 5A3 (Canada) |
| Abstract: | The design of molecular catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biological systems. Herein, we report how the bulky arms of the cations in (n C4H9)4N]+HCO3]‐ give rise to a host scaffold that emulates the substrate binding sites in carbonic anhydrase enzymes, affording a unique glimpse of an arrested intermediate in the base‐mediated binding and activation of CO2. |
| Keywords: | biomimetic system carbon dioxide carbonic anhydrases electronic structure enzyme models |