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Self‐Assembly Structure Formation during the Digestion of Human Breast Milk
Authors:Dr Stefan Salentinig  Stephanie Phan  Dr Adrian Hawley  Prof Ben J Boyd
Institution:1. Monash Institute of Pharmaceutical Sciences and ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology (BJB), Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052 (Australia);2. SAXS/WAXS Beamline, Australian Synchrotron, 800 Blackburn Rd, Clayton, VIC 3168 (Australia)
Abstract:An infant′s complete diet, human breast milk, is the basis for its survival and development. It contains water‐soluble and poorly water‐soluble bioactive components, metabolic messages, and energy, all of which are made bioavailable during the digestion process in the infant′s gastrointestinal tract. Reported is the first discovery of highly geometrically organized structures formed during the digestion of human breast milk under simulated in vivo conditions using small‐angle X‐ray scattering and cryogenic transmission electron microscopy. Time of digestion, pH, and bile salt concentration were found to have symbiotic effects gradually tuning the oil‐based environment inside the breast milk globules to more water‐like structures with high internal surface area. The structure formation is necessarily linked to its function as carriers for poorly water‐soluble molecules in the digestive tract of the infant.
Keywords:emulsions  lipids  milk  self‐assembly  vesicles
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