| ROLE OF CALCIUM IN ELECTRO-ACUPUNCTURE ANALGESIA AND THE DEVELOPMENTS OF ANALGESIC TOLERANCE TO ELECTROACUPUNTURE AND MORPHINE |
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| 作者姓名： | 张祖暄 张媛贞 贾淑萍 陆学健 余瑞荣 王新光 陈荣三 |
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| 作者单位： | Division of Physiology，Department of Biology，Nanjing University，Division of Physiology，Department of Biology，Nanjing University，Division of Physiology，Department of Biology，Nanjing University，Division of Physiology，Department of Biology，Nanjing University，Laboratory of Isotopes，Department of Biology，Nanjing University，Laboratory of Isotopes，Department of Biology，Nanjing University，Coordination Chemistry Research Institute，Nanjing University |
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| 基金项目： | Project supported by the National Natural Science Fundation China. |
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| 摘 要： | Role of brain Ca~(2+) in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibiturs of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca~(2+) and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca~(2+) and cAMP levels in the animals greatly reduced. From the changes of brain Ca~(2+) and cAMP levels, the analgesic effects by electro-acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morphine. These finding
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