Assembly of isoquinolines via CuI-catalyzed coupling of beta-keto esters and 2-halobenzylamines |
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| Authors: | Wang Bao Lu Biao Jiang Yongwen Zhang Yihua Ma Dawei |
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| Affiliation: | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China. |
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| Abstract: | CuI-catalyzed coupling of 2-halobenzylamines with beta-keto esters or 1,3-diketones in i-PrOH under the action of K(2)CO(3) produced 1,2-dihydroisoquinolines as the coupling/condensative cyclization products, which underwent smooth dehydrogenation under air atmosphere to afford substituted isoquinolines. |
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