An efficient and reusable heterogeneous catalyst Animal Bone Meal for facile synthesis of benzimidazoles, benzoxazoles, and benzothiazoles |
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Authors: | Yassin Riadi Rachid Mamouni Rachid AzzalouMohammadine El Haddad Sylvain RoutierGérald Guillaumet Saïd Lazar |
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Institution: | a Laboratoire de Biochimie, Environnement & Agroalimentaire, URAC 36, Université Hassan II Mohammedia-Casablanca, Mohammedia, Morocco b Laboratoire de Chimie Organique, Equipe de Chimie Bio-Organique Appliquée, Université Ibn Zohr, Agadir, Morocco c Département Sciences de la Matière, Faculté Poly-disciplinaire de Safi, Université Cadi Ayyad, Safi, Morocco d Institut de Chimie Organique & Analytique, Université d’Orléans, UMR CNRS 6005, Orléans, France |
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Abstract: | A library of benzimidazoles, benzoxazoles, and benzothiazoles was efficiently synthesized by condensation of o-phenylenediamine, o-aminophenol, and o-aminothiophenol respectively with aromatic aldehydes in the presence of catalytic amounts of Animal Bone Meal (ABM) and Lewis acids doped ABMs. Reactions were conducted under reflux conditions in air. The remarkable features of this new protocol are high conversion, short reaction times, and cleaner reaction profiles, straightforward procedure, and reduction in catalyst toxicity. |
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Keywords: | Animal Bone Meal Benzimidazoles Benzoxazoles Benzothiazoles Lewis acids Air |
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