Chemiluminescence determination of bufrenorphine hydrochloride by flow injection analysis |
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Authors: | Abdul A. Alwarthan Alan Townshend |
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Affiliation: | Chemistry Department, University of Hull, Hull HU6 7RX Great Britain |
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Abstract: | A direct, simple and rapid flow-injection method is described for determining buprenorphine hydrochloride (10?8–10?4 M) based on its chemiluminescent oxidation with potassium permanganate in polyphosphoric acid. The limit of detection is 1 × 10?8 M (0.5 pmol per injection) and the log-log calibration is linear up to 1 × 10?4 M; the r.s.d. is 0.7% for a 10 μg ml?1 solution (n = 10). The method is directly applicable to aqueous solutions of tablets containing the drug (0.2 mg/tablet). |
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