An electroanalytical study of the anticancer drug dacarbazine |
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Authors: | A.J.Miranda Ordieres A.Costa Garcia P.Tuñón Blanco W.Franklin Smyth |
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Affiliation: | Department of Physical and Analytical Chemistry, University of Oviedo, 33004 Oviedo, Asturias Spain;Department of Pharmacy, The Queen''s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL Great Britain |
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Abstract: | The electrochemical behaviour of dacarbazine [5-(3,3-dimethyl-1-triazenyl) imidazole-4-carboxamide; DTIC] was investigated by Tast and differential pulse polarography (d.p.p.) at the dropping mercury electrode, by cyclic and differential pulse voltammetry at the hanging mercury drop electrode and by anodic voltammetry at the glassy carbon electrode. Calibration graphs were obtained for 2×10?8?2×10?5 M DTIC by d.p.p., for 5×10?9?1×10?5 M by adsorptive stripping voltammetry ar a hanging mercury drop electrode, and for 1?10×10?5 M by high-performance liquid chromatography with oxidative amperometric detection at a glassy carbon electrode. The methods are compared and applied to determine DTIC added to blood serum after a simple clean-up procedure. |
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