Antioxidant activity of lipophilic vitamin c derivative in dipalmitoyl phosphatidylcholine vesicles — A stopped-flow esr kinetic study |
| |
| Authors: | L. -M. Wu F. -L. Guo Z. -L. Liu Y. -L. Zhang X. -Q. Jia Y. -C. Liu |
| |
| Affiliation: | 1. National Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, 730000, Gansu, China
|
| |
| Abstract: | The antioxidant reactivity of the lipophilic derivative of vitamin C, i.e., ascorbyl-6-palmitate (VC-16) was remarkably enhanced in dipalmitoyl phosphatidylcholine (DPPC) vesicles. The rate enhancement is tentatively explained by a vesicle fusion mechanism and subsequent lateral diffusion of reactants within the vesicle. The reduction of nitroxides incorporated into the vesicle by VCs was employed to examine the distribution of the nitroxide inside and outside the vesicle as well as the dynamic behaviour of the inside-outside transition (flip-flop). |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
