Catalyst‐Free Reaction in Water: Synthesis of Functionalized Tetrahydroindole Derivatives via Three‐Component Domino Reaction |
| |
| Authors: | Xian Feng Jianjun Wang Wei Lin Juanjuan Zhang Zhibin Huang Daqing Shi |
| |
| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China |
| |
| Abstract: | An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst‐free conditions, by simply combining a phenylglyoxal monohydrate, an enaminone, and a barbituric acid. The advantages of this method are that it is catalyst free, has an easy workup, provides good yields, and uses water as solvent, which make this procedure facile and practical. |
| |
| Keywords: | functionalized tetrahydroindole derivatives multi‐component reaction catalyst‐free aqueous medium green chemistry |
|
|
