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Facile Synthesis of 4‐H‐Pyran Derivatives Bearing Indole Skeleton via [3+3] Cyclization of 3‐Indolyl‐3‐oxopropanenitriles with Dialkyl Acetylenedicarboxylates and Isocyanides |
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| Authors: | Ping Song Lili Zhao Shunjun Ji |
| Affiliation: | 1. Analytic and Testing Center, Soochow University, Suzhou, Jiangsu 215123, China;2. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China |
| Abstract: | An efficient multicomponent reaction of 3‐indolyl‐3‐oxopropanenitriles with dialkyl acetylenedicarboxylates and isocyanides under mild conditions leading to highly functionalized 6‐(indol‐3‐yl)‐4H‐pyrans in moderate to good yields has been developed. |
| Keywords: | isocyanides indole [3+3] cyclization dialkyl acetylenedicarboxylates pyran derivatives |