Multicomponent Reactions for Diverse Synthesis of N‐Substituted and NH 1,4‐Dihydropyridines |
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| Authors: | Jieping Wan Youyi Zhou Yunyun Liu Zheng Fang Chengping Wen |
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| Institution: | 1. Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China;2. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China |
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| Abstract: | The multicomponent reactions of aldehydes, electron deficient alkynes and amines have been successfully performed to yield a number of symmetrical 2,6‐unsubstituted 1,4‐dihydropyridines (1,4‐DHPs). This method has been found generally applicable for the synthesis of both N‐substituted and N‐unsubstituted 1,4‐DHPs by employing secondary amine to activate the alkyne component via enaminoester intermediates. The present method runs through an enamine type activation, which is different from the known approach employing AcOH as solvent. |
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| Keywords: | multicomponent reactions enamine activation enaminoester 1 4‐dihydropyridine diversity |
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