Design and Synthesis of Polyoxazole‐based Macrocycles Tethered with a Phosphonate Group |
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| Authors: | Fuling Qi Lianxun Gao Fushe Han |
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| Affiliation: | 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China;2. University of Chinese Academy of Sciences, Beijing 100864, China;3. Key Lab of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China |
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| Abstract: | We present the design and synthesis of polyoxazole‐based macrocycles containing a phosphonate group. A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester, acid, and salt at the macrocyclic ring periphery. Such unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors. |
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| Keywords: | telomerase Telomestatin oxazole phosphonate macrocyclic compound |
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