Nano‐Fe3O4 Encapsulated‐Silica Particles Bearing 3‐Aminopropyl Group as a Magnetically Separable Catalyst for Efficient Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Compounds |
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| Authors: | Shuo Liu Yuxiang Ni Jianguo Yang Huanan Hu Anguo Ying Songlin Xu |
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| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000, China |
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| Abstract: | Knoevenagel condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, benzimidazol‐2‐acetonitrile and benzothiazole‐2‐acetonitrile proceeded very smoothly, catalyzed by nano‐Fe3O4 encapsulated‐silica particles supported primary amine. Both reaction time and yield are satisfying. The advantages of this catalyst are ease of preparation, non‐toxicity, low cost, ease of handling and recyclability. |
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| Keywords: | magnetic nanoparticle Knoevenagel condensation recyclability magnetic separation |
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