Supramolecular Nanofibers/Hydrogels of the Conjugates of Nucleobase,Saccharide, and Amino Acids

Three new hydrogelators based on the conjugates of three naturally occurring biological building blocks: nucleobase, saccharide, and amino acids, were explored. Being synthesized via a facile solid phase peptide synthesis route, the hydrogelators self‐assemble in water to afford supramolecular nanofibers and hydrogels. Transmission electron microscopy, oscillation rheometry, and circular dichroism reveal that the hydrogels consist of largely helix‐based nanofibers of the widths of 5–12 nm and exhibit storage moduli up to 1 kPa. These hydrogelators also exhibit excellent cell‐compatibility. This work illustrates a new platform for constructing molecular soft materials for nanobiotechnology.