| 拉曼光谱法与经典方法验证对乙酰氨基酚固体分散体 |
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| 引用本文： | 王玮,程黎,赵辉,李晓曼,曹凯,田京辉. 拉曼光谱法与经典方法验证对乙酰氨基酚固体分散体[J]. 光散射学报, 2011, 23(3): 263-270 |
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| 作者姓名： | 王玮 程黎 赵辉 李晓曼 曹凯 田京辉 |
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| 作者单位： | 河南大学药学院,开封,475004 |
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| 摘 要： | 制备对乙酰氨基酚固体分散体,采用拉曼光谱法与经典方法进行验证,以期获得一种新的简单易行的固体分散体的验证方法.以聚乙二醇6000(PEG6000)为载体,用熔融法和溶剂-熔融法制备对乙酰氨基酚固体分散体,在457.5 nm激发波长下扫描得到其拉曼光谱、10～90°(2θ)范围扫描获得X-射线粉末衍射图,经KBr压片后,...
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| 关 键 词： | 对乙酰氨基酚 固体分散体 拉曼光谱 X-射线衍射 红外光谱 |
| 收稿时间： | 2011-02-23 |
To Verify Paracetamol Solid Dispersion by Raman Spectrometry and the Classical Methods |
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| WANG Wei , CHENG Li , ZHAO Hui , LI Xiao-man , CAO Kai , TIAN Jing-hui. To Verify Paracetamol Solid Dispersion by Raman Spectrometry and the Classical Methods[J]. Chinese Journal of Light Scattering, 2011, 23(3): 263-270 |
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| Authors: | WANG Wei CHENG Li ZHAO Hui LI Xiao-man CAO Kai TIAN Jing-hui |
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| Affiliation: | WANG Wei,CHENG Li,ZHAO Hui,LI Xiao-man,CAO Kai,TIAN Jing-hui(Pharmaceutical College,Henan University,Kaifeng 475004,China) |
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| Abstract: | This study is to prepare the Paracetamol solid dispersion and to verify it with raman spectrometry and the classical methods,in order to obtain a new simple and easy verification method.PEG6000 acted as carrier,Paracetamol solid dispersion was prepared with melting and solvent-melting method,and verified by X-ray diffraction(XRD),fourier transform infrared spectrometry(FT-IR) and confocal microscopic raman spectrometry.Analytically the differences between solid dispersion and Paracetamol,carrier and physica... |
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| Keywords: | paracetamol solid dispersion Raman spectroscopy X-ray diffraction infrared spectroscopy |
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