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Grubbs carbene complex-catalyzed cleavage of allyl vic-diols to aldehydes with a co-oxidant: application to the selective cleavage of huge marine molecules |
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| Authors: | Chunguang HanYoshi Yamano Fumitoshi KakiuchiKazuhiko Nakamura Daisuke Uemura |
| Institution: | a Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan b Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan c Department of Chemistry, Faculty of Science, Kanagawa University, Hiratsuka, Kanagawa 259-1293, Japan |
| Abstract: | An oxidative cleavage of allyl vic-diols to aldehydes catalyzed by a Grubbs carbene complex using a co-oxidant has been established for the first time, with good yields. The utility of this selective cleavage reaction was demonstrated through the use of two huge marine molecules, symbiodinolide and N-p-BrBz palytoxin. |
| Keywords: | Grubbs carbene complex Catalytic reaction Marine huge molecule Degradation reaction |
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