| Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ)complex towards oxidized insulin B chain |
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| 作者姓名： | Jiang Jiang Qiong Jie Wu Xiang Yang Cai Long Gen Zhu Wen Ji Wang |
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| 作者单位： | a College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China;b College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;c State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China |
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| 摘 要： |
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| 关 键 词： | Zn(Ⅱ) complex |
| 收稿时间： | 11 June 2008 |
Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain |
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| Jiang Jiang,Qiong Jie Wu,Xiang Yang Cai,Long Gen Zhu,Wen Ji Wang.Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain[J].Chinese Chemical Letters,2009,20(1):71-75. |
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| Authors: | Jiang Jiang Qiong Jie Wub Xiang Yang Caib Long Gen Zhuc Wen Ji Wang a College of Chemistry Chemical Engineering Fuzhou University Fuzhou China b College of Life Science Fujian Agriculture Forestry University China c State Key Laboratory of Coordination Chemistry Nanjing University Nanjing China |
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| Institution: | a College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China;b College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;c State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China |
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| Abstract: | The electrospray ionization mass spectrometry investigation showed that the binding sites of ZnL]2+, where L is 2-bis(2-aminoethyl)aminolethanol, with oxidized insulin B chain are Phe1, His5 and Arg22, which lead to the selective cleavages of the peptide bonds at Phe1-Val2, His5-Leu6, Glu21-Arg22, and Arg22-Gly23 of oxidized insulin B chain. |
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| Keywords: | Oxidized insulin B chain Mass spectrometry Hydrolytic cleavage |
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