| 食品中甲硝唑残留的碳纳米管固相萃取-高效液相色谱法测定 |
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| 引用本文： | 倪晓丹,卢平,何旭伦,陈瑾. 食品中甲硝唑残留的碳纳米管固相萃取-高效液相色谱法测定[J]. 分析测试学报, 2010, 29(8). DOI: 10.3969/j.issn.1004-4957.2010.08.010 |
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| 作者姓名： | 倪晓丹 卢平 何旭伦 陈瑾 |
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| 作者单位： | 华南师范大学,化学与环境学院,广东,广州,510006 |
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| 摘 要： | 建立了以多壁碳纳米管为固相萃取吸附剂分离富集牛奶、鸡蛋以及蜂蜜中的甲硝唑残留,并用高效液相色谱法测定的分析方法。考察了碳纳米管对甲硝唑的吸附效果,洗脱剂的种类及其用量、碳纳米管的长度及大小和上样速率对萃取率的影响,优化了固相萃取条件。在优化实验条件下,方法的线性范围为0.01~10 mg/L,检出限为0.25μg/kg;对3种实际样品分别进行1、10、50μg/kg 3种水平下的加标回收实验,样品回收率为68%~112%,RSD为3.3%~17.1%,定量下限为0.8μg/kg。方法灵敏度高、简便快速且成本低,符合食品中低浓度兽药残留的分析方法要求。
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| 关 键 词： | 碳纳米管 固相萃取 甲硝唑 高效液相色谱法 |
Determination of Metronidazole in Food by HPLC with Multi-walled Carbon Nanotubes Solid-phase Extraction |
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| NI Xiao-dan,LU Ping,HE Xu-lun,CHEN Jin. Determination of Metronidazole in Food by HPLC with Multi-walled Carbon Nanotubes Solid-phase Extraction[J]. Journal of Instrumental Analysis, 2010, 29(8). DOI: 10.3969/j.issn.1004-4957.2010.08.010 |
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| Authors: | NI Xiao-dan LU Ping HE Xu-lun CHEN Jin |
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| Affiliation: | NI Xiao-dan,LU Ping,HE Xu-lun,CHEN Jin(School of Chemistry and Environment,South China Normal University,Guangzhou 510006,China) |
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| Abstract: | A novel method for the determination of metronidazole(MNZ) in milk,egg and honey was established by using multi-wall carbon nanotubes(MWCNTs) as solid-phase extraction adsorbent combined with high-performance liquid chromatography(HPLC).The adsorptivity of MWCNTs for metronidazole was evaluated,and the effects of experimental conditions,including type and volume of the eluent,length and diameter of MWCNTs as well as flow rate on the extraction efficiency were investigated.Under the optimized SPE conditions,... |
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| Keywords: | carbon nanotubes solid-phase extraction metronidazole high-performance liquid chromatography(HPLC) |
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