New dammarane-type saponins from the leaves of Panax notoginseng |
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Authors: | Jiwu Huang Chuangjun Li Junzi Cao Jie Ma Yiqian Du Xinyi Liu Jingzhi Yang Dongming Zhang |
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Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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Abstract: | Two new triterpenoid saponins named notoginsenoside-Ng3 (1) and notoginsenoside-Ng4 (2) along with three known saponins (3–5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover, compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L. |
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Keywords: | Notoginsenoside-Ng3 Notoginsenoside-Ng4 Single-crystal X-ray diffraction Acetylcholinesterase inhibitory activity |
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