| Synthesis of novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides |
| |
| 作者姓名： | Zhehui Zhao Apeng Wang Xiaoxi Zhang Shuang Yang Zhigang Luo Pingsheng Lei |
| |
| 作者单位： | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
| |
| 基金项目： | This work was supported by the CAMS Innovation Fund for Medical Sciences (Nos. 2017-I2M-3-011 and 2017-I2M-1-012). And we are grateful to the Department of Instrumental Analysis of our institute for performing the NMR and mass spectroscopy measurements. |
| |
| 摘 要： | A new and facile procedure was developed to synthesize novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.
|
| 收稿时间： | 29 January 2018 |
| 本文献已被 CNKI ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
