Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium |
| |
Authors: | Donohoe Timothy J Harris Robert M Burrows Jeremy Parker Jeremy |
| |
Affiliation: | Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK. timothy.donohoe@chem.ox.ac.uk |
| |
Abstract: | The double oxidative cyclization of dienes is a viable procedure for making complex natural products containing cis-THF units. A double deprotection/double oxidative cyclization strategy using catalytic osmium tetroxide was used to construct the bisheterocyclic core of cis-sylvaticin and ultimately confirm its structure. The natural product was then prepared by a short sequence of reactions that is exceptionally concise: the final route being just 13 linear steps and 19 chemical operations in total. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |