Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines

The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5-benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these (M+Ag](+)) compounds was observed. It was also found that M+Ag](+) produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the M+H](+) and M+Ag](+) precursor ions.