Synthesis of the alkaloids julandine and ipalbidine-use of silicon (IV) chloride |
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| Authors: | John E Cragg Stuart H Hedges Richard B Herbert |
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| Institution: | Department of Organic Chemistry, The University, Leeds LS2 9JT U.K. |
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| Abstract: | Titanium (IV) chloride and silicon (IV) chloride with high oxygen affinity are the best Lewis acid catalysts, of a number tested, for cyclisation of an enamine-ketone (1) leading to the alkaloid, julandine (2); cyclisation of (6) in methanol solution without catalyst yields -methylipalbidine (7) . |
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