Ring opening and closing reactions of imidazoles and other 1,3-diazaheterocycles with vinyl chloroformate and phenyl chloroformate |
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Authors: | RF Pratt KK Kraus |
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Institution: | Department of Chemistry Wesleyan University Middletown, CT 06457 U.S.A. |
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Abstract: | Treatment of imidazole and benzimidazole with vinyl chloroformate or phenyl chloroformate in weakly alkaline aqueous solution leads to their conversion into the corresponding imidazol-2-ones; in weakly acidic solutions these chloroformates convert adenine into isoguanine, 6-methylaminopurine into 1-methylisoguanine and pyrimidine into an acyclic product. |
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