Assymetric reduction of ketones using LiAlH4 modified with chiral 1,2-aminodiols.txt |
| |
Authors: | James D. Morrison Edward R. Grandbois Sachiko I. Howard Gary R. Weisman |
| |
Affiliation: | Department of Chemistry, Parsons Hall, University of New Hampshire, Durnham, New Hampshire 03824 USA |
| |
Abstract: | Four chiral aminodiols from ring opening of ()-propylene oxide and ethylene oxide wiht n-butylamine and () or ()-α-methylbenzylamine were used to modify LiAlH4. Assymetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric excess when the modifier was made from ()-oxide and ()-amine. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |