Assymetric reduction of ketones using LiAlH4 modified with chiral 1,2-aminodiols.txt

Four chiral aminodiols from ring opening of ($\text{S}$)-propylene oxide and ethylene oxide wiht n-butylamine and ($\text{R}$) or ($\text{S}$)-α-methylbenzylamine were used to modify LiAlH₄. Assymetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric excess when the modifier was made from ($\text{S}$)-oxide and ($\text{S}$)-amine.