CC bond formation from schiff base and vinyloxyborane: Synthesis of β-amino acid derivatives |
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Authors: | Masami Otsuka Makoto Yoshida Susumu Kobayashi Masaji Ohno Yoji Umezawa Hajime Morishima |
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Affiliation: | Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Tokyo 113, Japan;Institute of Microbial Chemistry Shinagawa-ku, Tokyo 141, Japan |
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Abstract: | An efficient methodology for the preparation of β-amino acid derivatives () by CC bond formation from Schiff bases () and vinyloxyborane () and their utilization in the synthesis of the pyrimidine moiety () of bleomycin are described. |
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