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CC bond formation from schiff base and vinyloxyborane: Synthesis of β-amino acid derivatives
Authors:Masami Otsuka  Makoto Yoshida  Susumu Kobayashi  Masaji Ohno  Yoji Umezawa  Hajime Morishima
Institution:Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Tokyo 113, Japan;Institute of Microbial Chemistry Shinagawa-ku, Tokyo 141, Japan
Abstract:An efficient methodology for the preparation of β-amino acid derivatives (3) by CC bond formation from Schiff bases (1) and vinyloxyborane (2) and their utilization in the synthesis of the pyrimidine moiety (3f) of bleomycin are described.
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