| 聚酰胺-胺(PAMAM)树状大分子对甲氨蝶呤的包合及缓释研究 |
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| 引用本文： | 叶玲,江晓舟,杨华,苏健婷,恽榴红. 聚酰胺-胺(PAMAM)树状大分子对甲氨蝶呤的包合及缓释研究[J]. 高等学校化学学报, 2005, 26(2): 353-355 |
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| 作者姓名： | 叶玲 江晓舟 杨华 苏健婷 恽榴红 |
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| 作者单位： | 1. 首都医科大学化学生物学与药学院,北京 100054;2. 军事医学科学院毒物药物研究所,北京 100850 |
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| 基金项目： | 北京市科技新星计划项目;北京市教委科技发展计划项目 |
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| 摘 要： | 以甲氨蝶呤(MTX)为模型药物,研究了G5.0PAMAM树状大分子对其包合和释放,并用13CNMR对PAMAM-MTX包合物进行了表征.UV-Vis研究结果表明,1个G5.0PAMAM树状大分子能包合27个MTX分子,体外释放研究表明,在37℃,pH=7.4的10mmol/LTris-HCl缓冲溶液中G5.0PAMAM树状大分子对MTX具有明显的缓释作用.
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| 关 键 词： | PAMAM树状大分子 甲氨蝶呤(MTX) 包合 缓释 |
| 文章编号： | 0251-0790(2005)02-0353-03 |
| 收稿时间： | 2004-01-14 |
Complex and in vitro Release of Methotrexate-PAMAM Dendrimer |
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| YE Ling,JING Xiao-Zhou,YANG Hua,SU Jian-Ting,YUN Liu-Hong. Complex and in vitro Release of Methotrexate-PAMAM Dendrimer[J]. Chemical Research In Chinese Universities, 2005, 26(2): 353-355 |
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| Authors: | YE Ling JING Xiao-Zhou YANG Hua SU Jian-Ting YUN Liu-Hong |
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| Affiliation: | 1. Capital University of Medical Sciences, Beijing 100054, China;2. Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | We investigated the interaction between G5^0 PAMAM and methotrexate(MTX) drug molecules by 13C NMR, and it has been proven that the interaction is occurring between the PAMAM amine functional groups and the MTX carboxyl groups. UV-Vis study showed each G5.0 PAMAM could conjugate up to 27 MTX molecules. The release of MTX from complex is much slower than that of free MTX at pH=7.4, 10 mmol/L Tris-HCl buffer. The presence of 0.02 mol/L NaCl in buffer increases the release rate of MTX from the complex, which further defines the interaction between PAMAM and MTX. |
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| Keywords: | Polyamidoamine(PAMAM) dendrimer Methotrexate(MTX) Release |
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