Synthesis of J-111,347, a novel 1 beta-methylcarbapenem with broad-spectrum antibacterial activity |
| |
| Authors: | Imamura H Ohtake N Sakuraba S Shimizu A Yamada K Morishima H |
| |
| Institution: | Banyu Tsukuba Research Institute, Ibaraki, Japan. |
| |
| Abstract: | Synthesis of J-111,347 (1), a new 1 beta-methylcarbapenem with broad-spectrum antibacterial activity including that against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, was achieved via diastereoselective preparation of a side-chain thiol 3 from an optically active (R)-3,4-dihydroxybutanal 4. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
