Stopped-flow determination of 2-mercaptopyrimidines as inductors of the iodine-azide reaction |
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| Authors: | Jan Kurzawa Agnieszka Wi?niewska Krystyna Janowicz |
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| Institution: | Institute of Chemistry, Poznań University of Technology, ul. Piotrowo 3, 60-965 Poznan, Poland |
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| Abstract: | A stopped-flow method for the determination of 2-mercaptopyrimidine and its 14 derivatives by the iodine-azide has been elaborated. Spectrophotometric detection was applied and the decrease in the absorbance of the iodine-starch complex was monitored at 595 nm within 5 s. The effect of the concentration of the reagents on the rate of the reaction was investigated and a kinetic method for determination of compounds is proposed. 2-Mercaptopyrimidines can be determined at 10−6 to 10−5 mol L−1 level and the relative standard deviation is below 1%. The elaborated method has been applied to the determination of 6-methyl- and 6-propyl-2-thiouracil in drugs. |
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| Keywords: | 2-Mecaptopyrimidines determination 2-Thiouracils Stopped-flow Iodine-azide |
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