Nestin-positive mesenchymal stem cells favour the astroglial lineage in neural progenitors and stem cells by releasing active BMP4 |
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Authors: | Email author" target="_blank">Sabine?Wislet-GendebienEmail author Fran?oise?Bruyère Grégory?Hans Pierre?Leprince Gustave?Moonen Bernard?Rogister |
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Institution: | 1.Centre for Cellular and Molecular Neurobiology,University of Liège,Liège,Belgium;2.Department of Neurology,C.H.U. of Liège,Sart Tilman,Belgium |
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Abstract: | Background Spontaneous repair is limited after CNS injury or degeneration because neurogenesis and axonal regrowth rarely occur in the
adult brain. As a result, cell transplantation has raised much interest as potential treatment for patients with CNS lesions.
Several types of cells have been considered as candidates for such cell transplantation and replacement therapies. Foetal
brain tissue has already been shown to have significant effects in patients with Parkinson's disease. Clinical use of the
foetal brain tissue is, however, limited by ethical and technical problems as it requires high numbers of grafted foetal cells
and immunosuppression. Alternatively, several reports suggested that mesenchymal stem cells, isolated from adult bone marrow,
are multipotent cells and could be used in autograft approach for replacement therapies. |
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