| MPPA光动力作用诱导人鼻咽癌细胞凋亡的实验研究 |
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| 引用本文： | 许川山,Albert Wing Nang Leung.MPPA光动力作用诱导人鼻咽癌细胞凋亡的实验研究[J].四川激光,2005,26(3):89-90. |
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| 作者姓名： | 许川山 Albert Wing Nang Leung |
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| 作者单位： | 重庆医科大学超声影像学研究所，Department of Chinese Medicine Education Division，School of Chinese Medicine，Hong Kong Baptist University，Hong Kong.，China 第二附属医院康复中心激光医学研究室，重庆400010Department of Chinese Medicine Education Division，School of Chinese Medicine，Hong Kong Baptist University，Hong Kong.，China |
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| 基金项目： | 国家自然科学基金资助 (编号 :3 0 3 0 0 468)，香港浸会大学FRG课题资助 |
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| 摘 要： | 为观察MPPa光动力作用对鼻咽癌细胞凋亡的影响,应用AnnexinV—PI双染结合流式细胞仪分析MPPa光动力作用后人鼻咽癌细胞株CNE2细胞发生凋亡和继发性坏死的比率。结果显示MPPa光动力作用实验组人鼻咽癌细胞株CNE2细胞发生凋亡和继发性坏死的比率分别增加到16.43 %和4.64 % ,且均显著高于单纯光照射组、单纯MMPa光敏剂处理组和假照射组(P <0 .0 1) ,而三对照组间无明显差异(P >0 .0 5 )。表明MPPa光动力作用能有效诱导低分化人鼻咽癌细胞株CNE2细胞凋亡的发生。这也可能是MPPa光动力作用杀伤鼻咽癌的重要机制之一。
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| 关 键 词： | 激光 MMPa 光动力治疗 鼻咽癌细胞 凋亡 |
| 文章编号： | 0253-2743(2005)03-0089-02 |
| 修稿时间： | 2004年4月5日 |
Study of MPPa-mediated Photodynamic therapy lnducing Human Nasopharyngeal Carcinoma Cells into Apoptosis |
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| XU Chuan-shan ,Albert Wing Nang Leung.Study of MPPa-mediated Photodynamic therapy lnducing Human Nasopharyngeal Carcinoma Cells into Apoptosis[J].Laser Journal,2005,26(3):89-90. |
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| Authors: | XU Chuan-shan Albert Wing Nang Leung |
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| Institution: | XU Chuan-shan 1,2,Albert Wing Nang Leung2 1.Institute of Ultrasound Imaging,Chongqing University of Medicine Sciences,Chongqing 400010,China,2.Department of Chinese Medicine Education Division,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong.,China |
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| Abstract: | To observe the effect of MMPa-mediated photodynamic therapy on apoptosis of human nasopharyngeal carcinoma cells,the apoptotic and secondary necrotic rate of the NPC CNE2 cells induced by MMPa-mediated photodynamic therapy was determined by flow cytometry with Annexin V-PI staining.The results showed that the apoptotic and secondary necrotic rate of the NPC CNE2 cells after photodynamic therapy significantly increased to 16.43% and 4.64%,and they were higher than those of the controls respectively(P<0.01).but there is no significance of the apoptotic and secondary necrotic rate between the controls(P>0.05).Our data demonstrate that MMpa-mediated photodynamic therapy might obviously trigger the NPC CNE2 cells into apoptosis,which might be one of the mechanisms of MMPa-mediated photodynamic therapy on nasopharyngeal carcinoma. |
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| Keywords: | laser pyropheophorbide-a methyl ester(MMPa) photodynamic therapy nasopharyngeal carcinoma apoptosis |
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