| A FACTOR(S) PRODUCED BY SERTOLI CELLS STIMULATES ANDROGEN BIOSYNTHESIS BY LEYDIG CELLS IN NEONATAL RATS |
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| 作者姓名： | 刘以训 KRISTINE D. DAHL |
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| 作者单位： | Laboratory of Reproductive Biology，Institute of Zoology，Academia Sinica，Beijing，Department of Reproductive Medicine，M-025 University of California，San Diego La Jolla，CA 92093，USA |
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| 基金项目： | This work was supported by the Rockefeller Foundation and National Institute of Health Research Grant HD14084. |
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| 摘 要： | Using a coculture system, we have studied the local action of Sertoli cells on Leydig cell function. The results show that (ⅰ) both LH and FSH have equal potency to stimulate testosterone biosynthesis by fetal and neonatal testicular cells in an age-dependent manner, the maximum stimulation is observed between D_3 and D_5. (ⅱ) An FSH-dependent factor(s) secreted by Sertoli cells increases the basal and/or LH-stimulated Leydig cell androgen production. (ⅲ) The Sertoli cell-stimulating factor(s) is not a steroid or other small molecule, but a heat-labile peptide.
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A FACTOR(S) PRODUCED BY SERTOLI CELLS STIMULATES ANDROGEN BIOSYNTHESIS BY LEYDIG CELLS IN NEONATAL RATS |
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| LIU YIXUN.A FACTOR(S) PRODUCED BY SERTOLI CELLS STIMULATES ANDROGEN BIOSYNTHESIS BY LEYDIG CELLS IN NEONATAL RATS[J].Science in China(Chemistry),1988(7). |
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| Authors: | LIU YIXUN |
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| Abstract: | |
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| Keywords: | Leydig cells Sertofi cells coculture factor testosterone production |
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