|
|||||
|
|
1H‐Benzotriazole as Synthetic Auxiliary in a Facile Route to N6‐(Arylmethyl)‐2′‐deoxyadenosines: DNA Intercalators Inserted into Three‐Way Junctions |
|
| Authors: | Sherif&#x;A El‐Kafrawy Magdy&#x;A Zahran Erik&#x;B Pedersen Claus Nielsen |
| Abstract: | The 2′‐deoxy‐N6‐(naphthalen‐1‐ylmethyl)‐ ( 5a ) and N6‐(pyren‐1‐ylmethyl)adenosine ( 5b ) were synthesized in two steps from 2′‐deoxyadenosine and the adequate arenecarbaldehyde with 1H‐benzotriazole as a synthetic auxiliary (Scheme). When the N6‐(arylmethyl)‐2′‐deoxyadenosines were inserted into the junction region of a DNA three‐way junction, its thermal stability increased. |
| Keywords: | |