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Antineoplastics Encapsulated in Nanostructured Lipid Carriers
Authors:Gustavo Henrique Rodrigues da Silva,Ludmilla David de Moura,Fabí  ola Vieira de Carvalho,Gabriela Geronimo,Talita Cesarim Mendonç  a,Fernando Freitas de Lima,Eneida de Paula
Affiliation:Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas—UNICAMP, Campinas 13083-862, Brazil; (G.H.R.d.S.); (L.D.d.M.); (F.V.d.C.); (G.G.); (T.C.M.); (F.F.d.L.)
Abstract:Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactants. NLC have high upload capacity for lipophilic drugs, such as the majority of AAs. These nanoparticles can be prepared with a diversity of biocompatible (synthetic or natural) lipid blends, administered by different routes and functionalised for targeting purposes. This review focused on the research carried out from 2000 to now, regarding NLC formulations for AAs (antimetabolites, antimitotics, alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for codelivery of AAs were also considered, as well as those for non-classical drugs and therapies (natural products and photosensitisers). NLC have emerged as powerful DDS to improve the bioavailability, targeting and efficacy of antineoplastics, while decreasing their toxic effect in the treatment of different types of cancer.
Keywords:antineoplastics   drug delivery   nanostructured lipid carriers   cancer
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