| 天花粉蛋白溶液构象与稳定性及生物活性的关系 |
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| 引用本文： | 田庚元,张孝先,沈春镒. 天花粉蛋白溶液构象与稳定性及生物活性的关系[J]. 化学学报, 1992, 50(9): 914-917 |
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| 作者姓名： | 田庚元 张孝先 沈春镒 |
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| 作者单位： | 中国科学院上海有机化学研究所，中国科学院上海有机化学研究所，中国科学院上海药物研究所 上海 200032，上海 200032，上海 200031 |
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| 摘 要： | 用圆二色性研究了天花粉蛋白在不同PH,不同温度和不同的时间条件下的溶液构象变化.阐明了天花粉蛋白溶液的外部环境,并研究了天花粉蛋白的溶液构象与抗生育活性的关系,结果表明随着溶液中a-helix含量的增加,抗生育活性也相应增加,当a-helix含量减少到15%以下,其抗生育活性也就丧失.
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| 关 键 词： | 稳定性 生物活性 圆振二向色性 溶液构象 天花粉蛋白 抗生育活性 |
The relationship of conformation ,stability and biological activity of trichosanthin in aqueous solution |
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| Abstract: | The conformation of trichosanthin in aqueous solution under different pH, temperature and keeping time has been investigated by CD. The stable external surroundings of trichosanthin solution, for example, pH, temperature and keeping time, has been explained. The relationship between the conformation of trichosanthin solution and the antireproductive activity has been also studied. The result showed that the a-helix in the solution has the pos. relation with antireproductive activity. Antireproductive activity increases along with the a-helix in the solution, and it disappears while a-helix in the solution decreases to less than 15%.- |
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| Keywords: | STABILITY BIOLOGICAL ACTIVITY CIRCULAR DICHROISM RICHOSATHIN PROTEIN |
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