First enantioselective total synthesis of (+)-(R)-Pinnatolide using an asymmetric domino allylation reaction |
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| Authors: | Tietze Lutz F Wolfram Thomas Holstein Julian J Dittrich Birger |
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| Affiliation: | Institute of Organic and Biomolecular Chemistry, Georg-August-University of G?ttingen, Tammannstr. 2, D-37077 G?ttingen, Germany. ltietze@gwdg.de |
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| Abstract: | An efficient total synthesis of (+)-(R)-Pinnatolide is described. As a key step an asymmetric multicomponent domino allylation reaction of methyl levulinate is used to form the quaternary stereogenic center in a highly selective way. |
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