A new and general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction |
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| Authors: | Micha? Mroczkiewicz |
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| Institution: | a Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
b Polish Academy of Sciences, Institute of Organic Chemistry, Kasprzaka 44/52, 01-224 Warsaw, Poland |
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| Abstract: | Tripeptide aldehydes, such as Z-Leu-Leu-Leu-H (MG-132), are an important class of compounds due to their biological activity. A new, general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction was developed. A careful choice of isocyanides makes it possible to obtain tripeptide precursors whose functionalization led to target structures. This method can be used for the preparation of tripeptide aldehydes with non-natural amino acid side chains. |
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