Alkynylcyanation of alkynes and dienes catalyzed by nickel |
| |
Authors: | Yasuhiro Hirata Tamejiro Hiyama |
| |
Affiliation: | Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan |
| |
Abstract: | Alkynyl cyanides are found to add across alkynes and 1,2-dienes in the presence of a catalyst prepared in situ from Ni(cod)2, xantphos, and BPh3. A range of functionalized conjugated cis-enynes are obtained with high regioselectivity. The addition reaction across norbornadiene proceeds in the absence of BPh3 to give exo-cis adduct exclusively. A stoichiometric reaction of an alkynyl cyanide, Ni(cod)2, xantphos, and BPh3 gives trans-(xantphos)Ni(CNBPh3)(CCSiMe2t-Bu), which is suggested to be a plausible reaction intermediate of the alkynylcyanation reaction. |
| |
Keywords: | Nickel Lewis acid Carbocyanation C-C bond activation Alkyne Diene |
本文献已被 ScienceDirect 等数据库收录! |
|