A Cu(I)-promoted one-pot ‘SNAr-click reaction’ of fluoronitrobenzenes |
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Authors: | Kulbhushan A Dururgkar |
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Institution: | National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India |
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Abstract: | A one-pot two-step sequence involving a nucleophilic aromatic substitution (SNAr) of activated fluorobenzenes with azide nucleophile and in situ Huisgen cycloaddition of the resulting aryl azides with alkynes has been developed for a rapid access to 1,4-substituted triazoles. Control experiments revealed that both the steps are catalyzed by Cu(I) and also the course of reaction as SNAr followed by 3+2]-cycloaddition. |
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