Rhodium(I)-catalyzed enantioselective 1,4-addition of nucleophilic silicon |
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| Authors: | Christian Walter |
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| Affiliation: | Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, D-48149 Münster, Germany |
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| Abstract: | A rhodium(I)-catalyzed activation of a silicon-boron linkage, that is, the transmetalation of silicon from boron to rhodium(I) by means of an RhI-OH complex, enables the conjugate transfer of nucleophilic silicon onto α,β-unsaturated acceptors. Pre- or in situ formed cationic rhodium(I)-binap complexes catalyze this novel carbon-silicon bond formation with exceptional enantiocontrol, 92 to >99% ee for cyclic carbonyl and carboxyl compounds as well as >99% ee for acyclic carboxyl compounds. |
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| Keywords: | Asymmetric catalysis Boron Conjugate addition Homogeneous catalysis Rhodium Silicon |
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