| β-环糊精手性识别D/L-樟脑磺酸的NMR研究 |
| |
| 引用本文： | 黄少华,柏正武,冯继文.β-环糊精手性识别D/L-樟脑磺酸的NMR研究[J].波谱学杂志,2009,26(4):457-465. |
| |
| 作者姓名： | 黄少华 柏正武 冯继文 |
| |
| 作者单位： | 1.波谱与原子分子物理国家重点实验室，武汉磁共振中心(中国科学院 武汉物理与数学研究所)，湖北 武汉 430071；2.中国科学院 研究生院，北京 100049；3.武汉工程大学 化工与制药学院，湖北 武汉 430073 |
| |
| 基金项目： | 国家自然科学基金资助项目（10474116，10674152） |
| |
| 摘 要： | 利用高分辨液体NMR技术考察了D2O中β-环糊精与手性药物D/L-樟脑磺酸对映体之间的相互作用，结果表明樟脑磺酸对映体能够进入β-环糊精的疏水空腔并与之发生手性相互作用. β-环糊精能够手性识别樟脑磺酸对映体. 化学计量关系实验和2D ROESY实验结果表明，樟脑磺酸对映体的疏水结构只能从β-环糊精疏水空腔的宽口端进入，并形成化学计量比为1∶1的非对映体络合物.
|
| 关 键 词： | 核磁共振（NMR） 手性识别 β-环糊精 樟脑磺酸 |
| 收稿时间： | 2009-05-30 |
| 修稿时间： | 2009-06-10 |
Enantiomeric Discrimination of D/L-10-Camphoric Sulfonic Acid by β-Cyclodextrins Studied by NMR Spectroscopy |
| |
| HUANG Shao-Hua,BAI Zheng-Wu,FENG Ji-Wen.Enantiomeric Discrimination of D/L-10-Camphoric Sulfonic Acid by β-Cyclodextrins Studied by NMR Spectroscopy[J].Chinese Journal of Magnetic Resonance,2009,26(4):457-465. |
| |
| Authors: | HUANG Shao-Hua BAI Zheng-Wu FENG Ji-Wen |
| |
| Institution: | 1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonace,(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China; 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China; 3.School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430073, Chin |
| |
| Abstract: | Chiral recognition of β-cyclodextrin (β-CD) to chiral drug D/L-10-camphoric sulfonic acid (CSA) was investigated using high resolution liquid state NMR spectroscopy. It was found that CSA can enter the hydrophobic cavity of β-CD and interact with it chirally. The results of 2D ROESY experiments suggested that the enantiomers of CSA enter into the hydrophobic cavity of β-CD from its wide brim, not from its narrow brim. Stoichiometry result showed a 1∶1 complex between the host and the guest. It was demonstrated that β-CD can be used to discriminate the enantiomers of CSA. |
| |
| Keywords: | NMR chiral recognition &beta -cyclodextrin camphoric sulfonic acid |
|
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
